| Date | Grid | Clue | Author | Editor |
|---|---|---|---|---|
| Fri, Apr 19, 2024 | 1D | Remedy after a night out, perhaps | Kate Hawkins | Fagliano |
| Sat, Feb 17, 2024 | 1A | Headache helper | Spencer Leach and Jem Burch | Shortz |
| Thu, Nov 10, 2022 | 46D | Aleve alternative | Dan Caprera | Shortz |
| Fri, Jun 24, 2022 | 8D | "Stronger than pain" sloganeer | Sophia Maymudes and Margaret Seikel | Shortz |
| Sun, Apr 28, 2019 | 31D | Motrin competitor | Brendan Emmett Quigley | Shortz |
| Fri, Feb 15, 2019 | 27A | Relief pitcher? | Wyna Liu | Shortz |
| Tue, Jan 29, 2019 | 6D | Excedrin competitor | Benjamin Kramer | Shortz |
| Mon, Oct 27, 2014 | 49D | Aleve alternative | Stanley Newman | Shortz |
| Mon, Nov 05, 2012 | 5A | Ibuprofen brand | Andrea Carla Michaels | Shortz |
| Sat, Aug 04, 2012 | 1D | Big name in relief | Jim Page | Shortz |
| Mon, Feb 08, 2010 | 61A | Popular pain reliever | Paula Gamache | Shortz |
| Tue, Nov 25, 2008 | 53D | Tylenol rival | Caleb Madison | Shortz |
| Sun, Jul 06, 2008 | 61D | Tylenol rival | Brendan Emmett Quigley | Shortz |
| Mon, Nov 28, 2005 | 29D | Aleve competitor | Kevan Choset | Shortz |
| Thu, Nov 03, 2005 | 34D | Tylenol alternative | Byron Walden | Shortz |
| Mon, Jun 21, 2004 | 30D | Tablet with ibuprofen | Craig Kasper | Shortz |
| Thu, Aug 23, 2001 | 26D | Motrin rival | Peter Gordon | Shortz |