| Date | Grid | Clue | Author | Editor |
| Sat, Feb 22, 2020 | 4D | The F.D.A. approved it in 1987 | Trenton Charlson | Shortz |
| Sat, May 26, 2018 | 4D | Drug marketed as Retrovir | Peter Wentz | Shortz |
| Sat, Dec 23, 2017 | 19A | Drug sought by Roy Cohn in "Angels in America" | Matthew Sewell | Shortz |
| Tue, Dec 06, 2016 | 22A | H.I.V. drug | Ed Sessa | Shortz |
| Tue, May 19, 2015 | 11A | HIV-treating drug | Allan E. Parrish | Shortz |
| Sun, Feb 01, 2015 | 29D | AIDS-fighting drug | David Steinberg | Shortz |
| Tue, Oct 28, 2014 | 6D | First anti-AIDS drug | Andrea Carla Michaels | Shortz |
| Wed, Feb 20, 2013 | 42A | H.I.V. drug | John Farmer | Shortz |
| Mon, Jan 02, 2012 | 37D | AIDS treatment drug | Paula Gamache | Shortz |
| Fri, Dec 30, 2011 | 48A | Drug sold under the brand name Retrovir | Mike Nothnagel | Shortz |
| Wed, May 25, 2011 | 61A | Drug taken in "Rent" | Jeff Dubner | Shortz |
| Tue, Sep 21, 2010 | 20A | Pioneering anti-AIDS drug | Adam G. Perl | Shortz |
| Tue, Oct 06, 2009 | 29D | First anti-AIDS drug | Matt Ginsberg | Shortz |
| Tue, Jan 15, 2008 | 42D | First drug approved to treat AIDS | Stella Daily and Bruce Venzke | Shortz |
| Fri, Jul 07, 2006 | 22A | Zidovudine, familiarly | Joe Krozel | Shortz |
| Thu, Nov 11, 2004 | 26A | Much talked-about antiviral drug, briefly | Michael Shteyman | Shortz |
| Fri, May 09, 2003 | 49A | Antiviral drug | Manny Nosowsky | Shortz |
| Sun, Nov 02, 1997 | 40D | Much-discussed drug | Nancy Nicholson Joline | Shortz |
| Tue, May 20, 1997 | 5D | Much-publicized drug | Elizabeth C. Gorski | Shortz |