| Date | Grid | Clue | Author | Editor |
| Thu, Jul 20, 2017 | 30A | Real downers | Randolph Ross | Shortz |
| Tue, Oct 16, 2012 | 59A | Certain sedatives | Bill Thompson | Shortz |
| Sat, Mar 20, 2010 | 49A | Heroin and the like | Joe Krozel | Shortz |
| Tue, Mar 31, 2009 | 50A | Morphine and codeine, for two | Allan E. Parrish | Shortz |
| Sun, Jan 11, 2009 | 84D | Numbers? | David J. Kahn | Shortz |
| Sat, Jun 07, 2003 | 35A | Some anodynes | Sherry O. Blackard | Shortz |
| Sun, Oct 20, 2002 | 111A | Sleep inducers | Harvey Estes and Nancy Salomon | Shortz |
| Wed, Sep 26, 2001 | 41A | Pain relievers | Stephen Budiansky | Shortz |
| Thu, Sep 13, 2001 | 18A | They may put you to sleep | Robert H. Wolfe | Shortz |
| Tue, Dec 02, 1997 | 47D | Tranquilizers | Alan Olschwang | Shortz |
| Sat, Jun 17, 1995 | 19A | Sedatives | Frank A. Longo | Shortz |
| Fri, Jul 15, 1994 | 38D | Anodynes | A.J. Santora | Shortz |