| Date | Grid | Clue | Author | Editor |
| Fri, Aug 23, 2024 | 11D | Oral vaccine target | Taylor Johnson and Rafael Musa | Fagliano |
| Wed, Dec 06, 2023 | 66A | Health problem now largely eradicated in the U.S. | Peter A. Collins and Bruce Haight | Shortz |
| Thu, Jul 02, 2020 | 15A | Study for Dr. Albert Sabin | Yacob Yonas and Chad Horner | Shortz |
| Wed, Feb 21, 2018 | 37D | Salk vaccine target | Ori Brian and Zachary Spitz | Shortz |
| Wed, May 04, 2016 | 63A | Vaccine target | Jacob Stulberg | Shortz |
| Sun, May 01, 2016 | 31A | Subject of the 1954 Nobel Prize in Medicine | Joel Fagliano and Byron Walden | Shortz |
| Tue, May 27, 2014 | 48D | Vaccine target | James Tuttle | Shortz |
| Thu, Apr 10, 2014 | 31A | Sabin's study | David Steinberg | Shortz |
| Sun, Mar 30, 2014 | 98A | Challenge for F.D.R. | Peter A. Collins | Shortz |
| Tue, Feb 11, 2014 | 52A | F.D.R.'s affliction | Matthew E. Paronto and Jeff Chen | Shortz |
| Mon, Apr 11, 2011 | 22D | Salk vaccine target | Ian Livengood | Shortz |
| Thu, Nov 08, 2007 | 46A | Vaccine target | Paula Gamache | Shortz |
| Sat, Feb 25, 2006 | 34A | Bygone epidemic cause | Henry Hook | Shortz |
| Wed, Jun 09, 2004 | 24D | Salk's conquest | Seth A. Abel | Shortz |
| Sun, Apr 11, 2004 | 36D | F.D.R. affliction | Patrick Merrell | Shortz |
| Mon, May 27, 2002 | 44D | Old disease | Norman Wizer | Shortz |
| Wed, Sep 20, 2000 | 68A | Salk's target | Edgar R. Fontaine | Shortz |
| Thu, Dec 02, 1999 | 27D | Salk's conquest | Mel Taub | Shortz |
| Wed, Oct 19, 1994 | 55A | Salk's conquest | D.J. Listort | Shortz |